Application
C4B Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the C4B antibody detected the C4B protein (arrow).| Product Name | C4B Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | C4A; CO4; CPAMD2; Complement C4-A; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CO4 CPAMD2 |
|---|---|
| Alternative Names | C4A CO4 CPAMD2 Complement C4-A Acidic complement C4 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 Complement C4 beta chain Complement C4-A alpha chain C4a anaphylatoxin C4b-A C4d-A Complement C4 gamma chain |
| Molecular Weight(MW) | 192785 Da |
| Function | Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens |
| Tissue Specificity | Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response |
| Cellular Localization | Secreted. |
| Entrez Gene | 720 |
|---|---|
| Nucleotide Accession | NP_001002029.3 |
Application
C4B Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the C4B antibody detected the C4B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
