Application
Western blot analysis of CABLES1 Antibody (C-term) in Jurkat cell line lysates (35ug/lane).CABLES1 (arrow) was detected using the purified Pab;Application
Western blot analysis of CABLES1 Antibody (C-term) in mouse heart tissue lysates (35ug/lane).CABLES1 (arrow) was detected using the purified Pab.Application
CABLES1 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CABLES1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | CABLES1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CABLES1; CABLES; CDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CABLES |
|---|---|
| Alternative Names | CABLES1 CABLES CDK5 and ABL1 enzyme substrate 1 Interactor with CDK3 1 |
| Molecular Weight(MW) | 67599 Da |
| Function | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) |
| Tissue Specificity | Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers |
| Cellular Localization | Nucleus (By similarity). Cytoplasm (By similarity). Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity) |
| Entrez Gene | 91768 |
|---|
Application
Western blot analysis of CABLES1 Antibody (C-term) in Jurkat cell line lysates (35ug/lane).CABLES1 (arrow) was detected using the purified Pab;
Application
Western blot analysis of CABLES1 Antibody (C-term) in mouse heart tissue lysates (35ug/lane).CABLES1 (arrow) was detected using the purified Pab.
Application
CABLES1 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CABLES1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
