Application
CADM1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the CADM1 antibody detected the CADM1 protein (arrow).Application
CADM1 Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CADM1 antibody detected the CADM1 protein (arrow).Application
CADM1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CADM1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | CADM1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CADM1; IGSF4; IGSF4A; NECL2; SYNCAM; TSLC1; Cell adhesion molecule 1; Immunoglobulin superfamily member 4; Nectin-like protein 2; Spermatogenic immunoglobulin superfamily; Synaptic cell adhesion molecule; Tumor suppressor in lung cancer 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IGSF4 IGSF4A NECL2 SYNCAM TSLC1 |
|---|---|
| Alternative Names | CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1 Cell adhesion molecule 1 Immunoglobulin superfamily member 4 Nectin-like protein 2 Spermatogenic immunoglobulin superfamily Synaptic cell adhesion molecule Tumor suppressor in lung cancer 1 |
| Molecular Weight(MW) | 48509 Da |
| Function | Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa |
| Tissue Specificity | This CADM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human CADM1. |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Cell junction, synapse (By similarity). Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder |
| Entrez Gene | 23705 |
|---|---|
| Nucleotide Accession | NP_001091987.1 |
Application
CADM1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the CADM1 antibody detected the CADM1 protein (arrow).
Application
CADM1 Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CADM1 antibody detected the CADM1 protein (arrow).
Application
CADM1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CADM1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
