Application
CASQ2 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CASQ2 antibody detected the CASQ2 protein (arrow).| Product Name | CASQ2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CASQ2; Calsequestrin-2; Calsequestrin, cardiac muscle isoform |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CASQ2 Calsequestrin-2 Calsequestrin cardiac muscle isoform |
|---|---|
| Molecular Weight(MW) | 46436 Da |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions |
| Tissue Specificity | This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2. |
| Cellular Localization | Sarcoplasmic reticulum lumen. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells |
| Entrez Gene | 845 |
|---|---|
| Nucleotide Accession | NP_001223.2 |
Application
CASQ2 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CASQ2 antibody detected the CASQ2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
