Application
CATSPER1 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CATSPER1 antibody detected the CATSPER1 protein (arrow).| Product Name | CATSPER1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CATSPER1; Cation channel sperm-associated protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CATSPER1 Cation channel sperm-associated protein 1 |
|---|---|
| Molecular Weight(MW) | 90091 Da |
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH |
| Tissue Specificity | Testis-specific. |
| Cellular Localization | Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail |
| Entrez Gene | 117144 |
|---|---|
| Nucleotide Accession | NP_444282.3 |
Application
CATSPER1 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CATSPER1 antibody detected the CATSPER1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
