Application
Western blot analysis of CBAA1 Antibody (N-term) in K562 cell line lysates (35ug/lane). CBAA1 (arrow) was detected using the purified Pab.| Product Name | CBAA1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CALC, CBARA1 |
|---|---|
| Alternative Names | MICU1 CALC CBARA1 Calcium uptake protein 1 mitochondrial Atopy-related autoantigen CALC Calcium-binding atopy-related autoantigen 1 Allergen=Hom s 4 Flags: Precursor |
| Molecular Weight(MW) | 54351 Da |
| Function | Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF- hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload Regulates glucose-dependent insulin secretion in pancreatic beta- cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG |
| Tissue Specificity | Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein |
| Entrez Gene | 10367 |
|---|
Application
Western blot analysis of CBAA1 Antibody (N-term) in K562 cell line lysates (35ug/lane). CBAA1 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
