Application
CBX5 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CBX5 antibody detected the CBX5 protein (arrow).| Product Name | CBX5 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | HP1A |
|---|---|
| Alternative Names | CBX5 HP1A Chromobox protein homolog 5 Antigen p25 Heterochromatin protein 1 homolog alpha |
| Molecular Weight(MW) | 22225 Da |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins |
| Tissue Specificity | This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-1117 amino acids from the Central region of human CBX5. |
| Cellular Localization | Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase |
| Entrez Gene | 23468 |
|---|---|
| Nucleotide Accession | NP_036249.1 NP_001120794.1 NP_001120793.1 |
Application
CBX5 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CBX5 antibody detected the CBX5 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
