Application
CC2D1A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CC2D1A antibody detected the CC2D1A protein (arrow).| Product Name | CC2D1A Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AKI1 |
|---|---|
| Alternative Names | CC2D1A AKI1 Coiled-coil and C2 domain-containing protein 1A Akt kinase-interacting protein 1 Five prime repressor element under dual repression-binding protein 1 Putative NF-kappa-B-activating protein 023N |
| Molecular Weight(MW) | 104062 Da |
| Function | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis |
| Tissue Specificity | This CC2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-172 amino acids from the N-terminal region of human CC2D1A. |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome |
| Entrez Gene | 54862 |
|---|---|
| Nucleotide Accession | NP_060191.3 |
Application
CC2D1A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CC2D1A antibody detected the CC2D1A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
