Application
Western blot analysis of CCKBR Antibody (N-term) in Jurkat cell line lysates (35ug/lane). CCKBR (arrow) was detected using the purified Pab;Application
Western blot analysis of CCKBR Antibody (N-term) in mouse NIH-3T3 cell line lysates (35ug/lane). CCKBR (arrow) was detected using the purified Pab.| Product Name | CCKBR Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CCKRB |
|---|---|
| Alternative Names | CCKBR CCKRB Gastrin/cholecystokinin type B receptor Cholecystokinin-2 receptor |
| Molecular Weight(MW) | 48419 Da |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system |
| Tissue Specificity | Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 887 |
|---|
Application
Western blot analysis of CCKBR Antibody (N-term) in Jurkat cell line lysates (35ug/lane). CCKBR (arrow) was detected using the purified Pab;
Application
Western blot analysis of CCKBR Antibody (N-term) in mouse NIH-3T3 cell line lysates (35ug/lane). CCKBR (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
