Application
CCNF Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CCNF Antibody detected the CCNF protein (arrow).Application
CCNF Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CCNF Antibody detected the CCNF protein (arrow).| Product Name | CCNF Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FBX1, FBXO1 |
|---|---|
| Alternative Names | CCNF FBX1 FBXO1 Cyclin-F F-box only protein 1 |
| Molecular Weight(MW) | 87640 Da |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Nucleus. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus |
| Entrez Gene | 899 |
|---|---|
| Nucleotide Accession | NP_001752.2 |
Application
CCNF Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CCNF Antibody detected the CCNF protein (arrow).
Application
CCNF Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CCNF Antibody detected the CCNF protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
