Application
CCR4 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CCR4 antibody detected the CCR4 protein (arrow).| Product Name | CCR4 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CMKBR4 |
|---|---|
| Alternative Names | CCR4 CMKBR4 C-C chemokine receptor type 4 K5-5 CD_antigen=CD194 |
| Molecular Weight(MW) | 41403 Da |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival |
| Tissue Specificity | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 1233 |
|---|---|
| Nucleotide Accession | NP_005499.1 |
Application
CCR4 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CCR4 antibody detected the CCR4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
