Application
A. Western blot analysis on (1) Jurkat, (2) K562, and (3) Daudi cell lysates using anti-CKR5/CCR5 (C-term) RabMAb (Cat. #AJ1414a); dilution 1:2,000.| Product Name | CCR5/CKR5 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | E164 |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000~10000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CMKBR5 |
|---|---|
| Alternative Names | CCR5 CMKBR5 C-C chemokine receptor type 5 HIV-1 fusion coreceptor CHEMR13 |
| Molecular Weight(MW) | 40524 Da |
| Function | Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates |
| Tissue Specificity | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 1234 |
|---|
Application
A. Western blot analysis on (1) Jurkat, (2) K562, and (3) Daudi cell lysates using anti-CKR5/CCR5 (C-term) RabMAb (Cat. #AJ1414a); dilution 1:2,000.| Application Notes | WB:1:1000~10000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
