Application
Western blot analysis of CD209 Antibody (Center) in HL-60 cell line lysates (35ug/lane). CD209 (arrow) was detected using the purified Pab.| Product Name | CD209 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CLEC4L |
|---|---|
| Alternative Names | CD209 CLEC4L CD209 antigen C-type lectin domain family 4 member L Dendritic cell-specific ICAM-3-grabbing non-integrin 1 CD_antigen=CD209 |
| Molecular Weight(MW) | 45775 Da |
| Function | Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA |
| Tissue Specificity | Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type II membrane protein (Probable) Isoform 3: Cell membrane; Single-pass type II membrane protein (Probable) Isoform 5: Cell membrane; Single-pass type II membrane protein (Probable) Isoform 7: Secreted (Probable). Isoform 9: Secreted (Probable). Isoform 11: Secreted (Probable). |
| Entrez Gene | 30835 |
|---|
Application
Western blot analysis of CD209 Antibody (Center) in HL-60 cell line lysates (35ug/lane). CD209 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
