Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Application
CDK5R1 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the CDK5R1 antibody detected the CDK5R1 protein (arrow).| Product Name | CDK5R1(p35) Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDK5R1; CDK5R; NCK5A; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 activator 1, p25; Tau protein kinase II 23 kDa su |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CDK5R NCK5A |
|---|---|
| Alternative Names | CDK5R1 CDK5R NCK5A Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 regulatory subunit 1 TPKII regulatory subunit Cyclin-dependent kinase 5 activator 1 p35 Cyclin-dependent kinase 5 activator 1 p25 Tau protein kinase II 23 kDa su |
| Molecular Weight(MW) | 34060 Da |
| Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII |
| Tissue Specificity | Brain and neuron specific. |
| Cellular Localization | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals |
| Entrez Gene | 8851 |
|---|
Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application
CDK5R1 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the CDK5R1 antibody detected the CDK5R1 protein (arrow).| Application Notes | IHC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
