Application
CENTG1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow).| Product Name | CENTG1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CENTG1, KIAA0167 |
|---|---|
| Alternative Names | AGAP2 CENTG1 KIAA0167 Arf-GAP with GTPase ANK repeat and PH domain-containing protein 2 Centaurin-gamma-1 GTP-binding and GTPase-activating protein 2 Phosphatidylinositol 3-kinase enhancer |
| Molecular Weight(MW) | 124674 Da |
| Function | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion |
| Tissue Specificity | Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart |
| Cellular Localization | Isoform 1: Cytoplasm. Nucleus. |
| Entrez Gene | 116986 |
|---|---|
| Nucleotide Accession | NP_001116244.1 NP_055585.1 |
Application
CENTG1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
