Application
CHD1L Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CHD1L antibody detected the CHD1L protein (arrow).| Product Name | CHD1L Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHD1L; ALC1; Chromodomain-helicase-DNA-binding protein 1-like; Amplified in liver cancer protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ALC1 |
|---|---|
| Alternative Names | CHD1L ALC1 Chromodomain-helicase-DNA-binding protein 1-like Amplified in liver cancer protein 1 |
| Molecular Weight(MW) | 100984 Da |
| Function | DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding |
| Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas |
| Cellular Localization | Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1 |
| Entrez Gene | 9557 |
|---|---|
| Nucleotide Accession | NP_004275.3 |
Application
CHD1L Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CHD1L antibody detected the CHD1L protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
