Application
CHM Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHM antibody detected the CHM protein (arrow).| Product Name | CHM Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHM; REP1; TCD; Rab proteins geranylgeranyltransferase component A 1; Choroideraemia protein; Rab escort protein 1; TCD protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | REP1 TCD |
|---|---|
| Alternative Names | CHM REP1 TCD Rab proteins geranylgeranyltransferase component A 1 Choroideraemia protein Rab escort protein 1 TCD protein |
| Molecular Weight(MW) | 73476 Da |
| Function | Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation |
| Tissue Specificity | This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM. |
| Entrez Gene | 1121 |
|---|---|
| Nucleotide Accession | NP_000381.1 |
Application
CHM Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHM antibody detected the CHM protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
