Application
CHMP6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHMP6 antibody detected the CHMP6 protein (arrow).| Product Name | CHMP6 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHMP6; VPS20; Charged multivesicular body protein 6; Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | VPS20 |
|---|---|
| Alternative Names | CHMP6 VPS20 Charged multivesicular body protein 6 Chromatin-modifying protein 6 Vacuolar protein sorting-associated protein 20 |
| Molecular Weight(MW) | 23485 Da |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes |
| Tissue Specificity | Ubiquitously expressed. |
| Cellular Localization | Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane (Probable). Note=Localizes to endosomal membranes |
| Entrez Gene | 79643 |
|---|---|
| Nucleotide Accession | NP_078867.2 |
Application
CHMP6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHMP6 antibody detected the CHMP6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
