Application
CHRDL1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHRDL1 antibody detected the CHRDL1 protein (arrow).Application
CHRDL1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CHRDL1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | CHRDL1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHRDL1; NRLN1; Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NRLN1 |
|---|---|
| Alternative Names | CHRDL1 NRLN1 Chordin-like protein 1 Neuralin-1 Neurogenesin-1 Ventroptin |
| Molecular Weight(MW) | 51168 Da |
| Function | Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development |
| Tissue Specificity | Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes |
| Cellular Localization | Secreted (Potential). |
Application
CHRDL1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHRDL1 antibody detected the CHRDL1 protein (arrow).
Application
CHRDL1 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CHRDL1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
