Application
CHRNA10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CHRNA10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.Application
CHRNA10 Antibody (Center) western blot analysis in NCI-H292,MDA-MB453,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CHRNA10 antibody detected the CHRNA10 protein (arrow).| Product Name | CHRNA10 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHRNA10; NACHRA10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NACHRA10 |
|---|---|
| Alternative Names | CHRNA10 NACHRA10 Neuronal acetylcholine receptor subunit alpha-10 Nicotinic acetylcholine receptor subunit alpha-10 |
| Molecular Weight(MW) | 49705 Da |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma |
| Tissue Specificity | Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell membrane; Multi-pass membrane protein (Probable) |
| Entrez Gene | 57053 |
|---|---|
| Nucleotide Accession | NP_065135.2 |
Application
CHRNA10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CHRNA10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
CHRNA10 Antibody (Center) western blot analysis in NCI-H292,MDA-MB453,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CHRNA10 antibody detected the CHRNA10 protein (arrow).| Application Notes | IHC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
