Application
Western blot analysis on (A) A375 (B) A431 (C) HepG2 and (D) Human testis lysates using anti-CITED-1 RabMAb (Cat. #AJ1187a).| Product Name | CITED-1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CITED1, MSG1, Cbp/p300-interacting transactivator 1, Melanocyte-specific protein 1 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR3417 |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50000~100000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MSG1 |
|---|---|
| Alternative Names | CITED1 MSG1 Cbp/p300-interacting transactivator 1 Melanocyte-specific protein 1 |
| Molecular Weight(MW) | 19896 Da |
| Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner |
| Tissue Specificity | Expressed only in melanocytes and testis. |
| Cellular Localization | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner |
| Entrez Gene | 4435 |
|---|
Application
Western blot analysis on (A) A375 (B) A431 (C) HepG2 and (D) Human testis lysates using anti-CITED-1 RabMAb (Cat. #AJ1187a).| Application Notes | WB:1:50000~100000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
