Application
CL052 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CL052 antibody detected the CL052 protein (arrow).| Product Name | CL052 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RITA; C12orf52; RBPJ-interacting and tubulin-associated protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C12orf52 |
|---|---|
| Alternative Names | RITA C12orf52 RBPJ-interacting and tubulin-associated protein |
| Molecular Weight(MW) | 28619 Da |
| Function | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis |
| Tissue Specificity | This CL052 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human CL052. |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear |
| Entrez Gene | 84934 |
|---|---|
| Nucleotide Accession | NP_116237.1 |
Application
CL052 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CL052 antibody detected the CL052 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
