Application
CLEC7A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CLEC7A antibody detected the CLEC7A protein (arrow).Application
CLEC7A Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CLEC7A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | CLEC7A Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CLEC7A; BGR; CLECSF12; DECTIN1; C-type lectin domain family 7 member A; Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BGR CLECSF12 DECTIN1 |
|---|---|
| Alternative Names | CLEC7A BGR CLECSF12 DECTIN1 C-type lectin domain family 7 member A Beta-glucan receptor C-type lectin superfamily member 12 Dendritic cell-associated C-type lectin 1 |
| Molecular Weight(MW) | 27627 Da |
| Function | Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity) |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein Isoform 6: Cytoplasm (Probable). |
| Entrez Gene | 64581 |
|---|---|
| Nucleotide Accession | NP_072092.2 NP_922940.1 NP_922939.1 |
Application
CLEC7A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CLEC7A antibody detected the CLEC7A protein (arrow).
Application
CLEC7A Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CLEC7A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
