Application
CLSTN1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CLSTN1 antibody detected the CLSTN1 protein (arrow).| Product Name | CLSTN1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CLSTN1; CS1; KIAA0911; Calsyntenin-1; Alcadein-alpha; Alzheimer-related cadherin-like protein; Non-classical cadherin XB31alpha; Soluble Alc-alpha; CTF1-alpha; C-terminal fragment 1-alpha |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CS1 KIAA0911 |
|---|---|
| Alternative Names | CLSTN1 CS1 KIAA0911 Calsyntenin-1 Alcadein-alpha Alzheimer-related cadherin-like protein Non-classical cadherin XB31alpha Soluble Alc-alpha CTF1-alpha C-terminal fragment 1-alpha |
| Molecular Weight(MW) | 109793 Da |
| Function | Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity) |
| Tissue Specificity | Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level) |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity). Nucleus Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1 |
| Entrez Gene | 22883 |
|---|---|
| Nucleotide Accession | NP_001009566.1 |
Application
CLSTN1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CLSTN1 antibody detected the CLSTN1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
