Application
CMKLR1 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CMKLR1 antibody detected the CMKLR1 protein (arrow).| Product Name | CMKLR1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CMKLR1; CHEMR23; DEZ; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CHEMR23 DEZ |
|---|---|
| Alternative Names | CMKLR1 CHEMR23 DEZ Chemokine-like receptor 1 G-protein coupled receptor ChemR23 G-protein coupled receptor DEZ |
| Molecular Weight(MW) | 42322 Da |
| Function | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2) |
| Tissue Specificity | Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs) High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Entrez Gene | 1240 |
|---|---|
| Nucleotide Accession | NP_004063.1 |
Application
CMKLR1 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CMKLR1 antibody detected the CMKLR1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
