Application
Western blot analysis of CNTN1 Antibody (Center) in A2058 cell line lysates (35ug/lane). CNTN1 (arrow) was detected using the purified Pab.| Product Name | CNTN1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CNTN1; Contactin-1; Glycoprotein gp135; Neural cell surface protein F3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CNTN1 Contactin-1 Glycoprotein gp135 Neural cell surface protein F3 |
|---|---|
| Molecular Weight(MW) | 113320 Da |
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity) |
| Tissue Specificity | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle |
| Cellular Localization | Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side |
| Entrez Gene | 1272 |
|---|
Application
Western blot analysis of CNTN1 Antibody (Center) in A2058 cell line lysates (35ug/lane). CNTN1 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
