Application
COPS7A Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the COPS7A antibody detected the COPS7A protein (arrow).Application
COPS7A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COPS7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | COPS7A Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COPS7A; CSN7A; DERP10; COP9 signalosome complex subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CSN7A DERP10 |
|---|---|
| Alternative Names | COPS7A CSN7A DERP10 COP9 signalosome complex subunit 7a Dermal papilla-derived protein 10 JAB1-containing signalosome subunit 7a |
| Molecular Weight(MW) | 30277 Da |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively |
| Tissue Specificity | Widely expressed. Expressed at high level in brain, heart and skeletal muscle |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 50813 |
|---|---|
| Nucleotide Accession | NP_057403.1 |
Application
COPS7A Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the COPS7A antibody detected the COPS7A protein (arrow).
Application
COPS7A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COPS7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
