Application
COPS8 Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the COPS8 antibody detected the COPS8 protein (arrow).| Product Name | COPS8 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COPS8; CSN8; COP9 signalosome complex subunit 8; COP9 homolog; JAB1-containing signalosome subunit 8 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CSN8 |
|---|---|
| Alternative Names | COPS8 CSN8 COP9 signalosome complex subunit 8 COP9 homolog JAB1-containing signalosome subunit 8 |
| Molecular Weight(MW) | 23226 Da |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively |
| Tissue Specificity | This COPS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human COPS8. |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 10920 |
|---|---|
| Nucleotide Accession | NP_006701.1 NP_937832.1 |
Application
COPS8 Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the COPS8 antibody detected the COPS8 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
