Application
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CK1a antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | CSNK1A1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CSNK1A1; Casein kinase I isoform alpha; CK1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:10~50 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CSNK1A1 Casein kinase I isoform alpha CK1 |
|---|---|
| Molecular Weight(MW) | 38915 Da |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45' May play a role in segregating chromosomes during mitosis |
| Tissue Specificity | This CK1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308~337 amino acids from the C-terminal region of human CK1a. |
| Cellular Localization | Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis |
| Entrez Gene | 1452 |
|---|
Application
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CK1a antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | IHC:1:10~50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
