Application
CXCR4 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CXCR4 antibody detected the CXCR4 protein (arrow).| Product Name | CXCR4 (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CXCR4; C-X-C chemokine receptor type 4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; NPYRL; Stromal cell-derived factor 1 receptor; CD_antigen=CD184 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CXCR4 C-X-C chemokine receptor type 4 FB22 Fusin HM89 LCR1 Leukocyte-derived seven transmembrane domain receptor NPYRL Stromal cell-derived factor 1 receptor CD_antigen=CD184 |
|---|---|
| Molecular Weight(MW) | 39746 Da |
| Function | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus |
| Tissue Specificity | Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated |
| Entrez Gene | 7852 |
|---|---|
| Nucleotide Accession | NP_001008540.1 |
Application
CXCR4 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CXCR4 antibody detected the CXCR4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
