Application
CYFIP1 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CYFIP1 antibody detected the CYFIP1 protein (arrow).| Product Name | CYFIP1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CYFIP1; KIAA0068; Cytoplasmic FMR1-interacting protein 1; Specifically Rac1-associated protein 1; p140sra-1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0068 |
|---|---|
| Alternative Names | CYFIP1 KIAA0068 Cytoplasmic FMR1-interacting protein 1 Specifically Rac1-associated protein 1 p140sra-1 |
| Molecular Weight(MW) | 145182 Da |
| Function | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers |
| Tissue Specificity | This CYFIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-618 amino acids from the C-terminal region of human CYFIP1. |
| Cellular Localization | Cytoplasm, perinuclear region (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity) |
| Entrez Gene | 23191 |
|---|---|
| Nucleotide Accession | NP_055423.1 NP_001028200.1 |
Application
CYFIP1 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CYFIP1 antibody detected the CYFIP1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
