Application
Western blot analysis of anti-CYP26B1 Antibody (C-term) in 293 cell line lysates (35ug/lane). CYP26B1(arrow) was detected using the purified Pab.Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26B1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Application
Western blot analysis of CYP26B1 (arrow) using rabbit polyclonal CYP26B1 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CYP26B1 gene.| Product Name | CYP26B1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CYP26B1; CYP26A2; P450RAI2; Cytochrome P450 26B1; Cytochrome P450 26A2; Cytochrome P450 retinoic acid-inactivating 2; Retinoic acid-metabolizing cytochrome |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:50~100 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CYP26A2 P450RAI2 |
|---|---|
| Alternative Names | CYP26B1 CYP26A2 P450RAI2 Cytochrome P450 26B1 Cytochrome P450 26A2 Cytochrome P450 retinoic acid-inactivating 2 Retinoic acid-metabolizing cytochrome |
| Molecular Weight(MW) | 57513 Da |
| Function | Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints |
| Tissue Specificity | Highly expressed in brain, particularly in the cerebellum and pons |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane; Peripheral membrane protein (By similarity) |
| Entrez Gene | 56603 |
|---|
Application
Western blot analysis of anti-CYP26B1 Antibody (C-term) in 293 cell line lysates (35ug/lane). CYP26B1(arrow) was detected using the purified Pab.
Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26B1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application
Western blot analysis of CYP26B1 (arrow) using rabbit polyclonal CYP26B1 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CYP26B1 gene.| Application Notes | WB:1:50~100 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
