Application
DACH2 Antibody (N-term) western blot analysis in HepG2,Jurkat cell line lysates (35ug/lane).This demonstrates the DACH2 antibody detected the DACH2 protein (arrow).| Product Name | DACH2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DACH2; Dachshund homolog 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | DACH2 Dachshund homolog 2 |
|---|---|
| Molecular Weight(MW) | 65323 Da |
| Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain |
| Tissue Specificity | This DACH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human DACH2. |
| Cellular Localization | Nucleus (Probable). |
| Entrez Gene | 117154 |
|---|---|
| Nucleotide Accession | NP_444511.1 NP_001132987.1 |
Application
DACH2 Antibody (N-term) western blot analysis in HepG2,Jurkat cell line lysates (35ug/lane).This demonstrates the DACH2 antibody detected the DACH2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
