Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity)
Tissue Specificity
Expressed in the brain, heart and eyes.
Cellular Localization
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules (By similarity)
Western blot analysis of anti-DCAMKL2 in Hela cell line lysate (35ug/lane).DCAMKL2(arrow) was detected using the purified Pab (1:60 dilution).
Application Notes
WB:1:100~500
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.