Application
DCC Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DCC antibody detected the DCC protein (arrow).Application
DCC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DCC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | DCC Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DCC; IGDCC1; Netrin receptor DCC; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IGDCC1 |
|---|---|
| Alternative Names | DCC IGDCC1 Netrin receptor DCC Colorectal cancer suppressor Immunoglobulin superfamily DCC subclass member 1 Tumor suppressor protein DCC |
| Molecular Weight(MW) | 158457 Da |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene |
| Tissue Specificity | Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 1630 |
|---|---|
| Nucleotide Accession | NP_005206.2 |
Application
DCC Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DCC antibody detected the DCC protein (arrow).
Application
DCC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DCC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
