Application
DEDD Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the DEDD antibody detected the DEDD protein (arrow).| Product Name | DEDD Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DEDD; DEDPRO1; DEFT; Death effector domain-containing protein; DEDPro1; Death effector domain-containing testicular molecule; FLDED-1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DEDPRO1 DEFT |
|---|---|
| Alternative Names | DEDD DEDPRO1 DEFT Death effector domain-containing protein DEDPro1 Death effector domain-containing testicular molecule FLDED-1 |
| Molecular Weight(MW) | 36794 Da |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity) |
| Tissue Specificity | Widely expressed with highest levels in testis |
| Cellular Localization | Cytoplasm. Nucleus, nucleolus (By similarity). Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity) Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells |
| Entrez Gene | 9191 |
|---|---|
| Nucleotide Accession | NP_001034800.1 |
Application
DEDD Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the DEDD antibody detected the DEDD protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
