Application
DEF6 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DEF6 antibody detected the DEF6 protein (arrow).| Product Name | DEF6 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DEF6; IBP; Differentially expressed in FDCP 6 homolog; IRF4-binding protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IBP |
|---|---|
| Alternative Names | DEF6 IBP Differentially expressed in FDCP 6 homolog IRF4-binding protein |
| Molecular Weight(MW) | 73910 Da |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity) |
| Tissue Specificity | Broadly expressed in the immune system and can be detected in T and B-cells |
| Cellular Localization | Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate |
| Entrez Gene | 50619 |
|---|---|
| Nucleotide Accession | NP_071330.3 |
Application
DEF6 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DEF6 antibody detected the DEF6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
