Application
Western blot analysis of DKK1 Antibody (N-term) in T47D cell line lysates (35ug/lane). DKK1 (arrow) was detected using the purified Pab.| Product Name | DKK1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DKK1; Dickkopf-related protein 1; SK |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | DKK1 Dickkopf-related protein 1 SK |
|---|---|
| Molecular Weight(MW) | 28672 Da |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease |
| Tissue Specificity | Placenta. |
| Cellular Localization | Secreted. |
| Entrez Gene | 22943 |
|---|
Application
Western blot analysis of DKK1 Antibody (N-term) in T47D cell line lysates (35ug/lane). DKK1 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
