Application
Western blot analysis of DNAJC2 Antibody (Center) in mouse Neuro-2a cell line lysates (35ug/lane). DNAJC2 (arrow) was detected using the purified Pab.| Product Name | DNAJC2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DNAJC2; MPHOSPH11; MPP11; ZRF1; DnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; Zuotin-related factor 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MPHOSPH11 MPP11 ZRF1 |
|---|---|
| Alternative Names | DNAJC2 MPHOSPH11 MPP11 ZRF1 DnaJ homolog subfamily C member 2 M-phase phosphoprotein 11 Zuotin-related factor 1 |
| Molecular Weight(MW) | 71996 Da |
| Function | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3' |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Nucleus. Cytoplasm, cytosol. |
| Entrez Gene | 27000 |
|---|
Application
Western blot analysis of DNAJC2 Antibody (Center) in mouse Neuro-2a cell line lysates (35ug/lane). DNAJC2 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
