Application
Dnmt3L-R322 western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DNMT3L antibody detected the DNMT3L protein (arrow).| Product Name | Dnmt3L Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DNMT3L; DNA (cytosine-5)-methyltransferase 3-like |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | DNMT3L DNA (cytosine-5)-methyltransferase 3-like |
|---|---|
| Molecular Weight(MW) | 43583 Da |
| Function | Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 |
| Tissue Specificity | Expressed at low levels in several tissues including testis, ovary, and thymus |
| Cellular Localization | Nucleus (Probable). |
| Entrez Gene | 29947 |
|---|
Application
Dnmt3L-R322 western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DNMT3L antibody detected the DNMT3L protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
