Application
DOK7 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DOK7 antibody detected the DOK7 protein (arrow).| Product Name | DOK7 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DOK7; C4orf25; Protein Dok-7; Downstream of tyrosine kinase 7 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C4orf25 |
|---|---|
| Alternative Names | DOK7 C4orf25 Protein Dok-7 Downstream of tyrosine kinase 7 |
| Molecular Weight(MW) | 53097 Da |
| Function | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK |
| Tissue Specificity | Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level) |
| Cellular Localization | Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity) Note=Accumulates at neuromuscular junctions (By similarity) |
| Entrez Gene | 285489 |
|---|---|
| Nucleotide Accession | NP_001158145.1 NP_775931.3 |
Application
DOK7 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DOK7 antibody detected the DOK7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
