Application
DPH1 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DPH1 antibody detected the DPH1 protein (arrow).| Product Name | DPH1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DPH1; DPH2L; DPH2L1; OVCA1; Diphthamide biosynthesis protein 1; DPH1 homolog; Diphthamide biosynthesis protein 2 homolog-like 1; Ovarian cancer-associated gene 1 protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DPH2L DPH2L1 OVCA1 |
|---|---|
| Alternative Names | DPH1 DPH2L DPH2L1 OVCA1 Diphthamide biosynthesis protein 1 DPH1 homolog Diphthamide biosynthesis protein 2 homolog-like 1 Ovarian cancer-associated gene 1 protein |
| Molecular Weight(MW) | 48805 Da |
| Function | Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors |
| Cellular Localization | Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization |
| Entrez Gene | 1801 |
|---|---|
| Nucleotide Accession | NP_001374.3 |
Application
DPH1 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DPH1 antibody detected the DPH1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
