Application
DTX3L Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the DTX3L antibody detected the DTX3L protein (arrow).| Product Name | DTX3L Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DTX3L; BBAP; E3 ubiquitin-protein ligase DTX3L; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; Rhysin-2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BBAP |
|---|---|
| Alternative Names | DTX3L BBAP E3 ubiquitin-protein ligase DTX3L B-lymphoma- and BAL-associated protein Protein deltex-3-like Rhysin-2 |
| Molecular Weight(MW) | 83554 Da |
| Function | Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation |
| Tissue Specificity | This DTX3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-482 amino acids from the Central region of human DTX3L. |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 151636 |
|---|---|
| Nucleotide Accession | NP_612144.1 |
Application
DTX3L Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the DTX3L antibody detected the DTX3L protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
