Application
DVL2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DVL2 antibody detected the DVL2 protein (arrow).| Product Name | DVL2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DVL2; Segment polarity protein dishevelled homolog DVL-2; DSH homolog 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | DVL2 Segment polarity protein dishevelled homolog DVL-2 DSH homolog 2 |
|---|---|
| Molecular Weight(MW) | 78948 Da |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity) |
| Tissue Specificity | This DVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 587-617 amino acids from the C-terminal region of human DVL2. |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity) |
| Entrez Gene | 1856 |
|---|---|
| Nucleotide Accession | NP_004413.1 |
Application
DVL2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DVL2 antibody detected the DVL2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
