Application
DYT1 Antibody (Cat. #AM2084a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the DYT1 antibody detected the DYT1 protein (arrow).| Product Name | DYT1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TOR1A; DQ2; DYT1; Torsin-1A; Dystonia 1 protein; Torsin family 1 member A |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 583CT1.1.3 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:500~8000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DQ2 DYT1 |
|---|---|
| Alternative Names | TOR1A DQ2 DYT1 Torsin-1A Dystonia 1 protein Torsin family 1 member A |
| Molecular Weight(MW) | 37809 Da |
| Function | May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged |
| Tissue Specificity | Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord |
| Cellular Localization | Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of the endoplasmic reticulum. The association with nuclear envelope is mediated by the interaction with TOR1AIP2. The Glu-303 del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmic reticulum |
| Entrez Gene | 1861 |
|---|---|
| Nucleotide Accession | NP_000104.1 |
Application
DYT1 Antibody (Cat. #AM2084a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the DYT1 antibody detected the DYT1 protein (arrow).| Application Notes | WB:1:500~8000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
