Application
EPAS1 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow).| Product Name | EPAS1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EPAS1; BHLHE73; HIF2A; MOP2; PASD2; Endothelial PAS domain-containing protein 1; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73; HIF-1-alpha-like factor; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; PAS dom |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHLHE73 HIF2A MOP2 PASD2 |
|---|---|
| Alternative Names | EPAS1 BHLHE73 HIF2A MOP2 PASD2 Endothelial PAS domain-containing protein 1 Basic-helix-loop-helix-PAS protein MOP2 Class E basic helix-loop-helix protein 73 HIF-1-alpha-like factor Hypoxia-inducible factor 2-alpha Member of PAS protein 2 PAS dom |
| Molecular Weight(MW) | 96459 Da |
| Function | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier Potent activator of the Tie-2 tyrosine kinase expression Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD |
| Tissue Specificity | Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells |
| Cellular Localization | Nucleus (Potential). |
| Entrez Gene | 2034 |
|---|---|
| Nucleotide Accession | NP_001421.2 |
Application
EPAS1 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the EPAS1 antibody detected the EPAS1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
