Application
EXOSC4 Antibody (Center) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the EXOSC4 antibody detected the EXOSC4 protein (arrow).| Product Name | EXOSC4 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EXOSC4; RRP41; SKI6; Exosome complex component RRP41; Exosome component 4; Ribosomal RNA-processing protein 41; p12A |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | RRP41 SKI6 |
|---|---|
| Alternative Names | EXOSC4 RRP41 SKI6 Exosome complex component RRP41 Exosome component 4 Ribosomal RNA-processing protein 41 p12A |
| Molecular Weight(MW) | 26383 Da |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs |
| Tissue Specificity | This EXOSC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from the Central region of human EXOSC4. |
| Cellular Localization | Cytoplasm. Nucleus, nucleolus. Nucleus. |
| Entrez Gene | 54512 |
|---|---|
| Nucleotide Accession | NP_061910.1 |
Application
EXOSC4 Antibody (Center) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the EXOSC4 antibody detected the EXOSC4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
