Application
FAP Antibody western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the FAP antibody detected the FAP protein (arrow).| Product Name | FAP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FAP; Seprase; 170 kDa melanoma membrane-bound gelatinase; Fibroblast activation protein alpha; Integral membrane serine protease |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | FAP Seprase 170 kDa melanoma membrane-bound gelatinase Fibroblast activation protein alpha Integral membrane serine protease |
|---|---|
| Molecular Weight(MW) | 87713 Da |
| Function | In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers |
| Tissue Specificity | Fibroblast specific. |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Note=Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma |
| Entrez Gene | 2191 |
|---|---|
| Nucleotide Accession | NP_004451.2 |
Application
FAP Antibody western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the FAP antibody detected the FAP protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
