Application
FBXO2 Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.Application
FBXO2 Antibody (C-term) western blot analysis in mouse brain tissue and HepG2,293 cell line lysates (35ug/lane).This demonstrates the FBXO2 antibody detected the FBXO2 protein (arrow).| Product Name | FBXO2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FBXO2; FBX2; F-box only protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | FCWB |
| FC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FBX2 |
|---|---|
| Alternative Names | FBXO2 FBX2 F-box only protein 2 |
| Molecular Weight(MW) | 33328 Da |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity) |
| Tissue Specificity | This FBXO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the C-terminal region of human FBXO2. |
| Cellular Localization | Cytoplasm (By similarity). Microsome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) |
| Entrez Gene | 26232 |
|---|---|
| Nucleotide Accession | NP_036300.2 |
Application
FBXO2 Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Application
FBXO2 Antibody (C-term) western blot analysis in mouse brain tissue and HepG2,293 cell line lysates (35ug/lane).This demonstrates the FBXO2 antibody detected the FBXO2 protein (arrow).| Application Notes | FC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
