Application
FBXO11 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FBXO11 antibody detected the FBXO11 protein (arrow).| Product Name | FBXO11 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FBX11, VIT1 |
|---|---|
| Alternative Names | FBXO11 FBX11 VIT1 F-box only protein 11 Vitiligo-associated protein 1 |
| Molecular Weight(MW) | 103585 Da |
| Function | Substrate recognition component of the a (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53 |
| Tissue Specificity | Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes |
| Cellular Localization | Nucleus. |
| Entrez Gene | 80204 |
|---|---|
| Nucleotide Accession | NP_001177203.1 |
Application
FBXO11 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FBXO11 antibody detected the FBXO11 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
